ROME: Argentines Walter Samuel and Diego Milito struck inside the last three minutes to give Inter Milan their first win in 10 games in a 2-0 success at Chievo on Friday while Napoli thumped Cagliari 6-3.
Inter gave coach Claudio Ranieri a vital boost ahead of Tuesday's crucial Champions League second round, second leg clash with Marseille at the San Siro.
The Italians, who won the competition two years ago, trail 1-0 from the first leg in France and many in Italy believe Ranieri's job depends on progress to the quarter-finals.
Inter toiled for 87 minutes in Verona and looked to be heading for their eighth blank in their last 10 games until the dramatic late finale.
The win moved them up to sixth in Serie A and boosted their hopes of securing a European finish.
The nerazzurri had lost seven of their previous nine matches, failing to score in any of those and it was easy to see why in the first half.
They had a great chance to take the lead when Francesco Acerbi needlessly handled in the box as Lucio tried to go around him.
But goalkeeper Stefano Sorrentino tipped Milito's penalty kick onto the post and Chievo survived.
Playmaker Wesley Sneijder then set his sights from distance but his dipping shot hit the bar.
Inter put together a sweeping move that ended with Dejan Stankovic hitting a volley just over.
It wasn't all one-way traffic, though, as Sergio Pellissier burst into the area but goalkeeper Julio Cesar saved his close range shot with Lucio putting the forward under pressure.
The best chance in the second half went Chievo's way as United States midfielder Michael Bradley fired a free-kick just over the bar.
That was until Inter's grandstand finish as Samuel headed home a Sneijder corner three minutes from time.
And in the very last minute Milito made amends for his earlier penalty miss as he headed in from captain Javier Zanetti's cross.
Napoli won for the sixth time in a row to move up to fourth, within two points of the final Champions League qualifying position for next season.
This game looked to be over by the half hour mark as Napoli stormed into a three goal lead, but there was far more drama to come.
Marek Hamsik made the most of a slip by Daniele Conti to move into space and lash a low drive from 25 yards inside the post on 10 minutes.
Nine minutes later Paolo Cannavaro headed home a free-kick from Ezequiel Lavezzi, although there was a hint of offside.
And then Argeninte forward Lavezzi burst down the right and his cross was turned home past his own keeper by Davide Astori.
The game seemed over but Joaquin Larrivey headed home Conti's free-kick on 37 minutes.
And moments later goalkeeper Morgan De Sanctis had to spoon the ball onto the post from Ribeiro's prod as Cagliari came close to a second.
Lavezzi was brought down by Michele Canini and dispatched the penalty himself before making way for the rested Edinson Cavani.
The Uruguay forward then teed up Walter Gargano to shoot home a left-footed volley.
Napoli's final goal came from a long punt from De Sanctis which Goran Pandev controlled before playing in Cristian Maggio to shoot home.
Either side of that Larrivey completed his hat-trick with a pair of headers from Victor Ibarbo crosses.
NEW YORK (Reuters Health) - Some elderly women with early-stage breast cancer may be getting extra treatment that does them little good but comes with costs and possible side effects, according to a new study.
Researchers found that about three-quarters of women 70 and older with stage I breast cancer were treated with radiation to stave off recurrences, in addition to standard breast-conserving surgery.
Current guidelines say it's generally okay to skip radiation in those patients, as it hasn't been shown to help them live longer.
One of the main issues with radiation is not that it has a really high complication rate. The question is, are the benefits really there?" said Dr. Cary Gross, from the Yale School of Medicine in New Haven, who worked on the study.
Some women have skin irritation or discomfort after radiation, while lung, bone or heart problems near the site of the radiation are much more rare, Gross said.
In addition, there's the inconvenience of getting to appointments -- which may be more of a burden in the elderly. Radiation therapy costs about $7,000, paid for in older people by Medicare.
In one 2004 study, researchers including Dr. Kevin Hughes from the Harvard Medical School in Boston found that adding radiation on top of breast-conserving surgery didn't improve survival in elderly stage I breast cancer patients, probably because of differences in tumor characteristics in older women.
That prompted the no-radiation option to be added to guidelines from the National Comprehensive Cancer Network in 2005, meaning optimal treatment of that group could include or not include radiation.
To see whether those changes affected care, Gross and his team analyzed data from close to 13,000 women, age 70 and older, who were covered by Medicare and diagnosed with stage I breast cancer between 2001 and 2007.
Of those women, almost 77 percent were treated with radiation along with breast-conserving surgery, with only a slight decline before and after the 2004 report and subsequent guidelines change.
Among women expected to live less than five years based on their age and other diseases, 44 percent received radiation before the report, and 41 percent after, according to findings published in the Journal of Clinical Oncology.
MORE TREATMENT, SIMILAR OUTCOME
In the 2004 study, one percent of women who had breast-conserving surgery and radiation had a cancer recurrence by five years, compared to four percent of those who only received surgery, also known as lumpectomy.
Those women were all also prescribed the breast cancer drug tamoxifen.
That means you have to basically treat 33 women (with radiation) in order to prevent one recurrence at five years," Gross told Reuters Health, noting that recurrences are treatable.
The problem is this: you don't know which of the 33 women is the one you're going to help."
When Hughes' team tracked the same women from the original report out ten years, the researchers still didn't find a difference in deaths between the two treatment groups.
Still, even after the guideline change, Gross said, doctors may chose to treat older women with radiation to feel like they're doing everything they can for their patients.
Hughes told Reuters Health that it's ?disappointing" more doctors haven't followed the evidence and stopped using radiation so far, but he expects that shift will come slowly.
As physicians we don't want to give any treatment to a patient that's not necessary," added Hughes, who didn't participate in the current study.
The researchers agreed that older women would gain from being more involved in decisions about their own cancer care.
We need to do a better job of allowing patients to make informed choices," Gross said.
Hughes said that older patients should also speak up and ask their doctors whether they really need radiation.
It's time to start decreasing the amount of treatment we're giving, if we're getting the same effect in the long run," he said.
SOURCE: http://bit.ly/xhxczy Journal of Clinical Oncology, online March 5, 2012.
ANAHEIM, Calif. (AP) ? Lightning McQueen and friends are about to get the green light at Disneyland.
The park announced Wednesday that Cars Land, based on the Disney-Pixar "Cars" movies, is the headliner of four new attractions opening June 15 at Disney California Adventure Park after a five-year expansion.
Cars Land will be 12 acres of rides, shops and restaurants based on the movie's town of Radiator Springs. Along with rides based on "A Bug's Life," Monsters, Inc." and "Toy Story," it further cements California Adventure as the Pixar park.
Also opening will be Buena Vista Street, based on Los Angeles the way it was when Walt Disney first saw it in the 1920s, and the Cathay Circle Theater, a recreation of the place where "Snow White and the Seven Dwarfs" premiered in 1937.
Scientists map new mechanism in brain's barrier tissuePublic release date: 8-Mar-2012 [ | E-mail | Share ]
Contact: Hans Christian Helms hch@farma.ku.dk 45-31-24-26-66 University of Copenhagen
Researchers at the University of Copenhagen have documented a previously unknown biological mechanism in the brain's most important line of defence: the blood-brain barrier. Scientists now know that the barrier helps maintain a delicate balance of glutamate, a vital signal compound in the brain. The research results have just been published in the scientific journal GLIA.
Glutamate is the most important activating transmitter substance in the brain. Vital in small amounts, it is toxic for the brain if the concentration becomes too high. Noise on the brain's signal lines can have fatal consequences and is involved in neurological diseases such as Alzheimer's disease, sclerosis and schizophrenia. Until now scientists believed that the glutamate balance was maintained by an interaction between different types of cells in the brain: Scientists map new mechanism in the brain
"We now know that the blood-brain barrier also plays a vital role in the process by 'vacuuming' so to speak the brain fluid for extraneous glutamate, which is then pumped into the blood where it does not have a damaging effect. This is new knowledge that can have enormous impact on future drug development. We have charted a biological mechanism that other scientists eventually can try to influence chemically, for example, in the form of medicine to limit cell death after a stroke. When the brain lacks oxygen, the glutamate level in the brain fluid increases dramatically, which kick starts a toxic chain reaction that kills cells", explains associate professor Birger Brodin.
The research results have just been published in the scientific journal GLIA.
A couple of years ago, researchers at the Faculty of Health and Medical Sciences modelled an artificial blood-brain barrier in the laboratory using brain cells from rats and calves. Ninety-five percent of all drugs tested for treating diseases originating in the central nervous system fail because they cannot pass through the blood-brain barrier, which is why it is so important to have a tool that can be used to negotiate the difficult path across the brain's effective border crossing.
However, the model is not just a potential screening tool. It can also inform scientists about the properties of the mysterious barrier and lead to new knowledge about the healthy brain and disease:
"Others have been on the trail of the hypothesis that the blood-brain barrier helps maintain the delicate glutamate balance in the brain. However, because of the model we created in the laboratory, we have been able to test the hypothesis successfully in a biological experiment for the first time ever", explains PhD student Hans Christian Helms, who is the main driver behind the development of the blood-brain barrier created in the laboratory.
Scientists discovered the new mechanism in the blood-brain barrier as they were trying to investigate how amino acids get into the brain:
"Many significant discoveries happen by accident to some extent. We start by having a theory that we want to investigate. We test the theory in the laboratory and sometimes we get unexpected results. It is often the unexpected results that lead us onto new paths and to scientific breakthrough", concludes Birger Brodin.
###
Contact:
PhD student
Hans Christian Helms
Faculty of Health and Medical Sciences
Cell: +45 31 24 26 66
Mail: hch@farma.ku.dk
Associate professor
Birger Brodin
Faculty of Health and Medical Sciences
Cell: +45 22 48 03 55
Mail: bbr@farma.ku.dk
Communications officer
Stine Rasmussen
Faculty of Health and Medical Sciences
Cell: +45 20 92 27 30
Mail: sr@farma.ku.dk
[ | E-mail | Share ]
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Scientists map new mechanism in brain's barrier tissuePublic release date: 8-Mar-2012 [ | E-mail | Share ]
Contact: Hans Christian Helms hch@farma.ku.dk 45-31-24-26-66 University of Copenhagen
Researchers at the University of Copenhagen have documented a previously unknown biological mechanism in the brain's most important line of defence: the blood-brain barrier. Scientists now know that the barrier helps maintain a delicate balance of glutamate, a vital signal compound in the brain. The research results have just been published in the scientific journal GLIA.
Glutamate is the most important activating transmitter substance in the brain. Vital in small amounts, it is toxic for the brain if the concentration becomes too high. Noise on the brain's signal lines can have fatal consequences and is involved in neurological diseases such as Alzheimer's disease, sclerosis and schizophrenia. Until now scientists believed that the glutamate balance was maintained by an interaction between different types of cells in the brain: Scientists map new mechanism in the brain
"We now know that the blood-brain barrier also plays a vital role in the process by 'vacuuming' so to speak the brain fluid for extraneous glutamate, which is then pumped into the blood where it does not have a damaging effect. This is new knowledge that can have enormous impact on future drug development. We have charted a biological mechanism that other scientists eventually can try to influence chemically, for example, in the form of medicine to limit cell death after a stroke. When the brain lacks oxygen, the glutamate level in the brain fluid increases dramatically, which kick starts a toxic chain reaction that kills cells", explains associate professor Birger Brodin.
The research results have just been published in the scientific journal GLIA.
A couple of years ago, researchers at the Faculty of Health and Medical Sciences modelled an artificial blood-brain barrier in the laboratory using brain cells from rats and calves. Ninety-five percent of all drugs tested for treating diseases originating in the central nervous system fail because they cannot pass through the blood-brain barrier, which is why it is so important to have a tool that can be used to negotiate the difficult path across the brain's effective border crossing.
However, the model is not just a potential screening tool. It can also inform scientists about the properties of the mysterious barrier and lead to new knowledge about the healthy brain and disease:
"Others have been on the trail of the hypothesis that the blood-brain barrier helps maintain the delicate glutamate balance in the brain. However, because of the model we created in the laboratory, we have been able to test the hypothesis successfully in a biological experiment for the first time ever", explains PhD student Hans Christian Helms, who is the main driver behind the development of the blood-brain barrier created in the laboratory.
Scientists discovered the new mechanism in the blood-brain barrier as they were trying to investigate how amino acids get into the brain:
"Many significant discoveries happen by accident to some extent. We start by having a theory that we want to investigate. We test the theory in the laboratory and sometimes we get unexpected results. It is often the unexpected results that lead us onto new paths and to scientific breakthrough", concludes Birger Brodin.
###
Contact:
PhD student
Hans Christian Helms
Faculty of Health and Medical Sciences
Cell: +45 31 24 26 66
Mail: hch@farma.ku.dk
Associate professor
Birger Brodin
Faculty of Health and Medical Sciences
Cell: +45 22 48 03 55
Mail: bbr@farma.ku.dk
Communications officer
Stine Rasmussen
Faculty of Health and Medical Sciences
Cell: +45 20 92 27 30
Mail: sr@farma.ku.dk
[ | E-mail | Share ]
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
NO WONDER cancer is such a challenge to treat: a genetic analysis of advanced kidney cancer has shown that mutations can vary across the same tumour. This finding dashes hopes of tailoring treatment for an individual based on the mutations in a single biopsy.
Charles Swanton at Cancer Research UK in London and colleagues analysed kidney tumours from four people and found that around two-thirds of genetic mutations in the same tumour differed from one biopsy to the next.
The prognosis for each person was sometimes good and at other times bad depending on which part of the tumour was sampled.
It could explain why drugs that target specific mutations aren't always successful, says Swanton, whose results appear this week in The New England Journal of Medicine, vol 366, p 883.
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Written By: Shawn Winters?on?March 6, 2012No Comment
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Public release date: 8-Mar-2012
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